Wednesday, January 15, 2014

Glioblastoma & The Most Vital Components

Glioblastoma & The Most Vital Components

By Rob Sutter


GEN posted an article about glioblastoma, which is heavily regarded as one of the most serious conditions in the body. It's not hard to see why, as it is seen as the most common and aggressive form of brain cancer known. Keep in mind that this condition accounts for 15% or so of all tumors found in adults. Studies are going to have to be done in order to expand on the matter and there are a few components that should be looked to as well.

Before looking into the matter of research, though, it's worth noting what exactly makes glioblastoma tumors as severe as they seem to be. The report spoke about this in detail, saying that they possess many different types of cells, stem cells included amongst them. These are able to perpetuate cell growth and maintenance, which plays into the ongoing nature of this serious condition. This is one of the many reasons why it has the focus of various organizations on the matter, Voices against Brain Cancer included.

There was a study done by a group of researchers seen within the Montreal Neurological Institute and Hospital at McGill University. The group in question put to use an in vivo mouse model that would oversee the activity seen in human GBM-derived brain tumor initiating cells. FOXG1 and TLE were the two proteins looked into and it was determined that they could play into the shifts seen in various genes as well. It's clear that there is attention brought to the potential regulators of this serious condition.

It's clear that there is a lot of focus that goes into the various methods tied to research in general. Keep in mind that while methods like standard surgery and chemotherapy exist, they may not be as positively impacting in the long term. This means that there has to be attention brought to other areas of this level of research, which is why there has been such focus on elements like FOXG1 and TLE. Seeing as how they can come together in order to decrease activity in tumors, the aforementioned attention is appropriate.

I can only hope that this will be the case for glioblastoma research in the long term. In my mind, it's the type of condition that should be given more focus, which is fortunate considering the litany of stories that exist on the Internet about it. Of course, certain components are focused on more so than others, as it is believed that they can help bring rise to new therapies in the future. In time, I am sure that even more findings will come about based on the information uncovered so far.




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